| 1981 Week 5
- Buffalo Bills 23, Baltimore Colts 17
- Denver Broncos 17, Oakland Raiders 0
- Green Bay Packers 27, New York Giants 14
- Houston Oilers 17, Cincinnati Bengals 10
- Los Angeles Rams 27, Cleveland Browns 16
- Miami Dolphins 28, New York Jets 28 (OT)
- Minnesota Vikings 24, Chicago Bears 21
- New England Patriots 33, Kansas City Chiefs 17
- Philadelphia Eagles 16, Atlanta Falcons 13
- Pittsburgh Steelers 20, New Orleans Saints 6
- San Diego Chargers 24, Seattle Seahawks 10
- San Francisco 49ers 30, Washington Redskins 17
- St. Louis Cardinals 20, Dallas Cowboys 17
- Tampa Bay Buccaneers 28, Detroit Lions 10
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