| 1981 Week 1
- Atlanta Falcons 27, New Orleans Saints 0
- Baltimore Colts 29, New England Patriots 28
- Buffalo Bills 31, New York Jets 0
- Cincinnati Bengals 27, Seattle Seahawks 21
- Dallas Cowboys 26, Washington Redskins 10
- Denver Broncos 9, Oakland Raiders 7
- Detroit Lions 24, San Francisco 49ers 17
- Green Bay Packers 16, Chicago Bears 9
- Houston Oilers 27, Los Angeles Rams 20
- Kansas City Chiefs 37, Pittsburgh Steelers 33
- Miami Dolphins 20, St. Louis Cardinals 7
- Philadelphia Eagles 24, New York Giants 10
- San Diego Chargers 44, Cleveland Browns 14
- Tampa Bay Buccaneers 21, Minnesota Vikings 13
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