| Week 4 Games
  San Francisco 49ers 35, St. Louis Rams 11 |
| Arizona Cardinals 13, Tampa Bay Buccaneers 10 |
| Buffalo Bills 23, Baltimore Ravens 20 |
| Cleveland Browns 17, Cincinnati Bengals 6 |
| Detroit Lions 40, Chicago Bears 32 |
| Indianapolis Colts 37, Jacksonville Jaguars 3 |
| Kansas City Chiefs 31, New York Giants 7 |
| Minnesota Vikings 34, Pittsburgh Steelers 27 at London, England |
| Seattle Seahawks 23, Houston Texans 20 (OT) |
| Tennessee Titans 38, New York Jets 13 |
| Denver Broncos 52, Philadelphia Eagles 20 |
| San Diego Chargers 30, Dallas Cowboys 21 |
| Washington Redskins 24, Oakland Raiders 14 |
| New England Patriots 30, Atlanta Falcons 23 |
| New Orleans Saints 38, Miami Dolphins 17 |
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